In this second situation, the increase above normal is most dramatic. In those cases, your pet’s immune system is either responding to a perceived threat (bacteria, virus, parasites, allergy or severe stress) or it is malfunctioning (a hyperplastic, precancerous or cancerous state). In that case, your pet’s A:G ratio will be low. When tests show that the amount of specific blood globulin protein(s) in your pet are elevated, the condition is called hypergammaglobulinema. The amount of globulin in your pet’s blood also affects it’s A:G ratio. Or its liver may no longer be working adequately enough to produce sufficient albumin. When too little albumin is present in your pet’s blood, it may be because it is nutritionally deprived. In those cases, the globulin level will increase as well. When too much albumin is present in your dog or cat’s blood, it is most commonly caused by dehydrated. Those protein antibodies are produced by your pet’s immune system. The largest portion of your pet’s globulins are IgG (aka antibodies). Of that total protein, albumin comprises about 55% and globulins comprise about 35%. In health dogs and cats, these two proteins combined make up about 7% of their blood serum. The A:G ratio number is the amount of albumin protein in your dog or cat’s blood divided by the amount of globulin proteins in your pet’s blood. Your Dog And Cat’s Albumin To Globulin Ratio – A:G Ratio Ron Hines DVM PhDĬauses Of Most Abnormal Blood & Urine Tests
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